Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1-{6-[1-(2-Chloro-4,6-dimethylphenylimino)ethyl]pyridin-2-yl}ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | p-Toluenesulfonic acid | HCID 6101 | — |
| 반응물 | 2,6-Diacetylpyridine | HCID 70790 | — |
| 반응물 | 2-Chloro-4,6-dimethylaniline | HCID 113033 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 1-{6-[1-(2-Chloro-4,6-dimethylphenylimino)ethyl]pyridin-2-yl}ethanone | HCID 59464624 | 5.1% |
반응 단계
10 g of 2,6-diacetylpyridine (0.0613 mol), 9.54 g of 2-chloro-4,6-dimethylaniline (0.0613 mol) and 0.6 g of p-toluenesulfonic acid were heated under reflux on a water separator in 400 ml of methanol for 90 min. The solvent was distilled off completely and the residue was recrystallized twice from 50 ml of isopropanol. 0.92 g (0.0031 mol) of 1-{6-[1-(2-chloro-4,6-dimethyl-phenylimino)ethyl]pyridin-2-yl}ethanone was obtained in a yield of 5%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08252875B2 |
| 출처 데이터셋 | uspto-grants-2012_08 |
| ORD ID | ord-2a00147b60d54063851410655042b711 |
| 출처 메모 | uspto-grants-2012_08 |