N1,5'-O-dibenzyl-2',3'-didehydro-2',3'-dideoxyinosine → N1,5'-O-dibenzyl-2',3'-dideoxyinosine

HRID 889574노트

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HRID 889574 반응식
[CH2:1]([N:8]1[CH:30]=[N:29][C:28]2[N:13]([C@@H:14]3[O:27][C@H:17]([CH2:18][O:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH:16]=[CH:15]3)[CH:12]=[N:11][C:10]=2[C:9]1=[O:31])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>[C].[Pd].CO>[CH2:1]([N:8]1[CH:30]=[N:29][C:28]2[N:13]([C@@H:14]3[O:27][C@H:17]([CH2:18][O:19][CH2:20][C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH2:16][CH2:15]3)[CH:12]=[N:11][C:10]=2[C:9]1=[O:31])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 11683075N1,5'-O-dibenzyl-2',3'-didehydro-2',3'-dideoxyinosineHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 11647353N1,5'-O-dibenzyl-2',3'-dideoxyinosine수율 90%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

To a methanol solution (1 mL) of N1,5′-O-dibenzyl-2′,3′-didehydro-2′,3′-dideoxyinosine (207 mg, 0.5 mmol), 5% palladium-carbon (20 mg) was added, and the mixture was stirred at room temperature for 2 hours in an atmosphere of hydrogen (1 atm). The palladium catalyst was removed from the obtained reaction mixture by filtration, and the resultant filtrate was concentrated under reduced pressure. After purification by chromatography (using 15 g of silica gel and ethyl acetate as an eluting solution), 187 mg of the intended product was obtained in a yield of 90% as a white solid.

후처리

  1. customThe palladium catalyst was removed from the obtained reaction mixture by filtration
  2. concentrationthe resultant filtrate was concentrated under reduced pressure
  3. customAfter purification by chromatography (
  4. customwas obtained in a yield of 90% as a white solid

출처 및 근거

ORD 기록
ord-0b6a2586d998423c9507f8712130dcc1
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08252920B2

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