Potassium Cyanide → Methyl 5-cyanopentanoate

HRID 889579

반응식

HRID 889579 반응식
[C-:1]#[N:2].[K+].Br[CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10]>O.CO>[C:1]([CH2:5][CH2:6][CH2:7][CH2:8][C:9]([O:11][CH3:12])=[O:10])#[N:2]

참가 물질

5

반응물 2

HCID 9032Potassium CyanideHCID 79557Methyl 5-bromovalerate

생성물 1

HCID 554130Methyl 5-cyanopentanoate수율 74.3%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Potassium Cyanide (4 g, 61.44 mmol) is dissolved in 70 mL water and 200 mL methanol. To the solution 10 g (51.2 mmol) of methyl 5-bromopentanoate is added and the mixture is refluxed overnight. The reaction mixture is concentrated to dryness. To the residue, 100 mL of EtOAc is added to extract the product. The organic is washed with water three times, dried and concentrated to yield 5.37 g (74%) of methyl 5-cyanopentanoate as an oil.

후처리

  1. temperaturethe mixture is refluxed overnight
  2. concentrationThe reaction mixture is concentrated to dryness
  3. additionTo the residue, 100 mL of EtOAc is added
  4. extractionto extract the product
  5. washThe organic is washed with water three times
  6. customdried
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1b8890dafda348389a075e1b117b04a4
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08252923B2

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