Methanesulfinyl chloride → HCID 58545437, 화합물

HRID 889662

반응식

HRID 889662 반응식
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][NH2:9])=[CH:4][CH:3]=1.[CH3:10][S:11](Cl)=[O:12]>O1CCCC1>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][NH:9][S:11]([CH3:10])=[O:12])=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 548463Methanesulfinyl chlorideHCID 70209275-(Aminomethyl)-2-chloropyridine

생성물 1

HCID 58545437HCID 58545437, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Methanesulfinyl chloride was obtained as described in the literature. A solution of C-(6-chloro-pyridin-3-yl)-methylamine (2.1) (25 g, 178 mmol) in tetrahydrofuran (200 ml) was cooled to 0° C. and methanesulfinyl chloride (7 g, 71 mmol) was added dropwise. The solution was allowed to warm to room temperature and stirred for 16 hours. The precipitate was removed by filtration, the filtrate was diluted with EtOAc and washed with H2O. The organic phase was dried over Na2SO4 and evaporated under reduced pressure.

후처리

  1. customThe precipitate was removed by filtration
  2. additionthe filtrate was diluted with EtOAc
  3. washwashed with H2O
  4. dry with materialThe organic phase was dried over Na2SO4
  5. customevaporated under reduced pressure

출처 및 근거

ORD 기록
ord-3be19a7127c34e83a55bdf5cf018e576
출처 데이터셋
uspto-grants-2012_08
특허 번호
US08252939B2

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