Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 2-[3-(4-tert-Butyldiphenylsilyloxymethylphenyl)propyl]-[1,3]-dioxolane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | tert-Butyldiphenylchlorosilane | HCID 94078 | — |
| 반응물 | [4-(3-[1,3]-Dioxan-2-yl-propyl)phenyl]methanol | HCID 19694137 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2-[3-(4-tert-Butyldiphenylsilyloxymethylphenyl)propyl]-[1,3]-dioxolane | HCID 19694134 | 102.9% |
반응 단계
To a solution of 2.58 g (11.6 mmol) of alcohol 170 and 1.19 g (17.5 mmol) of imidazole in 50 mL of CH2Cl2 was added 3.4 mL (13.1 mmol) of tert-butylchlorodiphenyl silane and the resulting mixture was allowed to stir at room temperature for 1 h. The mixture was then diluted with ethyl acetate and washed with 0.5N HCl. The organic layer was dried over MgSO4, filtered and concentrated. Flash chromatography (elution with 5% ethyl acetate in hexane) afforded 5.5 g of 171. 1H NMR consistent with the product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05723459 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-2c93e9ea79a9405d9591cb8af2288670 |
| 출처 메모 | uspto-grants-1998_03 |