Norleucine, D-(-)- → Hexanoic acid, 2-hydroxy-, (2R)-
반응식
N[C@@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH2:4][CH2:5][CH3:6].N([O-])=[O:11].[Na+]>S(=O)(=O)(O)O.O>[OH:11][C@H:2]([CH2:3][CH2:4][CH2:5][CH3:6])[C:7]([OH:9])=[O:8]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
To a cooled (0° C.), stirred solution of D-norleucine (500 mg, 3.81 mmol) in 10 mL of 1N aqueous sulfuric acid was added sodium nitrite (421 mg, 6.10 mmol) in 3 mL of water dropwise over a 20-minute period. The reaction mixture was allowed to slowly warm to room temperature over a 16-hour period. The mixture then was extracted with EtOAc (2×25 mL), dried (Na2SO4), and concentrated to yield 200 mg (40%) of a white waxy solid.
후처리
- temperatureto slowly warm to room temperature over a 16-hour period
- extractionThe mixture then was extracted with EtOAc (2×25 mL)
- dry with materialdried (Na2SO4)
- concentrationconcentrated
- customto yield 200 mg (40%) of a white waxy solid
출처 및 근거
- ORD 기록
- ord-179b506ce4f74a2ca29ba9e4692847d9
- 출처 데이터셋
- uspto-grants-2006_02
- 특허 번호
- US06998416B2
반응 노트
불러오는 중…