Potassium Iodide → Methyl 2-acetylhexanoate
반응식
[CH3:1][O:2][C:3](=[O:8])/[CH:4]=[C:5](/[O-:7])\[CH3:6].[Na+].[I-].[K+].[CH2:12](Br)[CH2:13][CH2:14][CH3:15]>CN1CCCN(C)C1=O>[C:5]([CH:4]([CH2:12][CH2:13][CH2:14][CH3:15])[C:3]([O:2][CH3:1])=[O:8])(=[O:7])[CH3:6]참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
30 g (217 mmol) of sodium (2E)-4-methoxy-4-oxo-2-buten-2-olate (Example 13A) suspended in 1,3-dimethyltetrahydro-2(1H)-pyrimidone and 1.24 g (7.5 mmol) of potassium iodide are treated dropwise with 29.8 g (217 mmol) of butyl bromide and the mixture is stirred at 80° C. for 1 h under reflux. The cooled mixture is then added to ice water and extracted with diethyl ether. The ether phase is washed with sodium thiosulphate solution, dried, concentrated and chromatographed. The eluent used is cyclohexane having an increasing ethyl acetate content.
후처리
- temperatureunder reflux
- extractionextracted with diethyl ether
- washThe ether phase is washed with sodium thiosulphate solution
- customdried
- concentrationconcentrated
- customchromatographed
출처 및 근거
- ORD 기록
- ord-d000757376de4d02a6ce64ed2ce04c11
- 출처 데이터셋
- uspto-grants-2006_02
- 특허 번호
- US06998402B2
반응 노트
불러오는 중…