Triethylamine → 4-[2-Chloromethyl-4-phenyloxazol-5-yl]benzenesulfonamide

HRID 890876

반응식

HRID 890876 반응식
O[CH2:2][C:3]1[O:4][C:5]([C:14]2[CH:19]=[CH:18][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:16][CH:15]=2)=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1.C(N(CC)CC)C.[Cl-].[Li+].CS([Cl:37])(=O)=O>O1CCCC1.C(OCC)(=O)C>[Cl:37][CH2:2][C:3]1[O:4][C:5]([C:14]2[CH:19]=[CH:18][C:17]([S:20]([NH2:23])(=[O:22])=[O:21])=[CH:16][CH:15]=2)=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[N:7]=1

참가 물질

7

반응물 4

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 433294Lithium ChlorideHCID 222462434-[2-Hydroxymethyl-4-phenyloxazol-5-yl]benzenesulfonamide

생성물 1

HCID 222463454-[2-Chloromethyl-4-phenyloxazol-5-yl]benzenesulfonamide

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 8857Ethyl Acetate용매

실험 절차

A solution of 4-[2-hydroxymethyl-4-phenyloxazol-5-yl]benzenesulfonamide (Step 2) (1.0 g, 3 mmol) and triethylamine (0.61 g, 6 mmol) was stirred in tetrahydrofuran (100 mL) at 0° C. Lithium chloride (0.25 g, 6 mmol) was added, followed by the dropwise addition of methanesulfonyl chloride (0.38 g, 3.3 mmol). After stirring for 3 h from 0° C. to 25° C., ethyl acetate (100 mL) was added, and the mixture was washed with 1N hydrochloric acid, brine and water, dried over magnesium sulfate, filtered, and concentrated. The crude product was purified by flash column chromatography on silica gel eluting with a 1:1 mixture of ethyl acetate:hexanes. The appropriate fractions were concentrated to a clear oil which solidified upon standing to give 4-[2-chloromethyl-4-phenyloxazol-5-yl]benzenesulfonamide as a white solid which was used in the next step without further purification or characterization.

후처리

  1. washthe mixture was washed with 1N hydrochloric acid, brine and water
  2. dry with materialdried over magnesium sulfate
  3. filtrationfiltered
  4. concentrationconcentrated
  5. customThe crude product was purified by flash column chromatography on silica gel eluting with a 1:1 mixture of ethyl acetate
  6. concentrationThe appropriate fractions were concentrated to a clear oil which

출처 및 근거

ORD 기록
ord-48034f2a508343779fed85cf2b7a0f26
출처 데이터셋
uspto-grants-2006_02
특허 번호
US06998415B2

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