(3,5-Difluorophenyl)boronic acid → HCID 22244579, 화합물
반응식
I[C:2]1[C:3]([CH3:17])=[N:4][N:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][OH:16])=[CH:10][CH:9]=2)[C:6]=1[CH3:7].[F:18][C:19]1[CH:20]=[C:21](B(O)O)[CH:22]=[C:23]([F:25])[CH:24]=1>>[F:18][C:19]1[CH:20]=[C:21]([C:2]2[C:3]([CH3:17])=[N:4][N:5]([C:8]3[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][OH:16])=[CH:10][CH:9]=3)[C:6]=2[CH3:7])[CH:22]=[C:23]([F:25])[CH:24]=1참가 물질
3
실험 절차
The title compound was prepared according to the procedure described in step 1 of Example 12 from 2-[4-(4-iodo-3,5-dimethyl-1H-pyrazol-1-yl)phenyl]ethanol (step 2 of Example 11) and 3,5-difluorobenzeneboronic acid: MS (ESI) m/z 329 [M+H]+, 1H-NMR (CDCl3) δ 7.70-7.63 (1H, m), 7.55-7.33 (4H, m), 6.87-6.73 (2H, m), 3.89 (2H, t, J=6.2 Hz), 2.93 (2H, t, J=6.6 Hz), 2.33 (3H, s), 2.30 (3H, s).
출처 및 근거
- ORD 기록
- ord-6e85dcc7cfe54c9c9525a1dcebf1bcfd
- 출처 데이터셋
- uspto-grants-2006_02