2-Fluorobenzenesulfonamide → N-[({2-[4-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino)carbonyl]-2-fluorobenzenesulfonamide

HRID 891101

반응식

HRID 891101 반응식
[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23](=O)[O:24]C3C=CC=CC=3)=[CH:16][CH:15]=2)[N:3]=1.[F:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][C:34]=1[S:39]([NH2:42])(=[O:41])=[O:40]>>[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23]([NH:42][S:39]([C:34]3[CH:35]=[CH:36][CH:37]=[CH:38][C:33]=3[F:32])(=[O:41])=[O:40])=[O:24])=[CH:16][CH:15]=2)[N:3]=1

참가 물질

3

반응물 2

HCID 1936632-FluorobenzenesulfonamideHCID 22244550Phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate

생성물 1

HCID 11533294N-[({2-[4-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino)carbonyl]-2-fluorobenzenesulfonamide

실험 절차

The title compound was prepared according to the procedure described in step 2 of Example 22 from phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate (step 1 of Example 22) and 2-fluorobenzenesulfonamide: 1H-NMR (CDCl3) δ 7.89 (1H, t, J=6.9 Hz), 7.45-7.06 (12H, m), 6.48 (1H, br.s), 3.46-3.36 (2H, m),2.77-2.71 (2H, m), 2.28 (3H, s), 2.21 (3H, s).

출처 및 근거

ORD 기록
ord-08634919adcf42edaef484b0535d7993
출처 데이터셋
uspto-grants-2006_02
특허 번호
US07001917B2

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