3-Chloropyridine-2-sulfonamide → 3-Chloro-N-[({2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino)carbonyl]-2-pyridinesulfonamide

HRID 891121노트

반응식

HRID 891121 반응식
[CH3:1][C:2]1[C:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[C:5]([CH3:13])[N:4]([C:14]2[CH:19]=[CH:18][C:17]([CH2:20][CH2:21][NH:22][C:23](=[O:31])OC3C=CC=CC=3)=[CH:16][CH:15]=2)[N:3]=1.[Cl:32][C:33]1[C:34]([S:39]([NH2:42])(=[O:41])=[O:40])=[N:35][CH:36]=[CH:37][CH:38]=1>>[Cl:32][C:33]1[C:34]([S:39]([NH:42][C:23]([NH:22][CH2:21][CH2:20][C:17]2[CH:18]=[CH:19][C:14]([N:4]3[C:5]([CH3:13])=[C:6]([C:7]4[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=4)[C:2]([CH3:1])=[N:3]3)=[CH:15][CH:16]=2)=[O:31])(=[O:40])=[O:41])=[N:35][CH:36]=[CH:37][CH:38]=1

참가 물질

3

반응물 2

HCID 146531913-Chloropyridine-2-sulfonamideHCID 22244550Phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate

생성물 1

HCID 222446823-Chloro-N-[({2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethyl}amino)carbonyl]-2-pyridinesulfonamide

실험 절차

The title compound was prepared according to the procedure described in step 1 of Example 42 from phenyl 2-[4-(3,5-dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethylcarbamate (step 1 of Example 22) and 3-chloro-2-pyridinesulfonamide (U.S. Pat. No. 4,490,380): 1H-NMR (DMSO-d6) δ 8.62 (1H, d, J=4.3 Hz), 8.20 (1H, d, J=7.9 Hz), 7.71-7.67 (1H, m), 7.49-7.31 (9H, m), 6.57 (1H, br.s), 3.37-3.28 (2H, m), 2.79-2.74 (2H, m), 2.27 (3H, s), 2.23 (3H, s).

출처 및 근거

ORD 기록
ord-2db3c76701744d63a3e8b52a18ecae71
출처 데이터셋
uspto-grants-2006_02
특허 번호
US07001917B2

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