5-Chloro-3-(2-methylimidazol-1-ylmethyl)-pyridazine → 5-(7-Difluoromethyl-naphthalen-2-yl)-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine Hydrochloride
반응식
[F:1][CH:2]([F:22])[C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][C:9](B3OC(C)(C)C(C)(C)O3)=[CH:10]2)=[CH:5][CH:4]=1.[Cl:23][C:24]1[CH:25]=[C:26]([CH2:30][N:31]2[CH:35]=[CH:34][N:33]=[C:32]2[CH3:36])[N:27]=[N:28][CH:29]=1>>[ClH:23].[F:22][CH:2]([F:1])[C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[CH:8][C:9]([C:24]3[CH:25]=[C:26]([CH2:30][N:31]4[CH:35]=[CH:34][N:33]=[C:32]4[CH3:36])[N:27]=[N:28][CH:29]=3)=[CH:10]2)=[CH:5][CH:4]=1참가 물질
3
실험 절차
The title compound, MS: m/e=351.3 (M+H+), was prepared from 2-(7-difluoromethyl-naphthalen-2-yl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane and 5-chloro-3-(2-methyl-imidazol-1-yl-methyl)-pyridazine.
출처 및 근거
- ORD 기록
- ord-ac5ca2a1eb1b4b219b1fecf30c48644e
- 출처 데이터셋
- uspto-grants-2006_02
- DOI