p-Toluenesulfonic acid monohydrate → 3-(2-Quinolin-2-yl-vinyl)-phenol

HRID 892143노트

반응식

HRID 892143 반응식
COCCOC[O:7][C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([CH:14]=[CH:15][C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:17]=2)[CH:9]=1.O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N:17]1[C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:24]=[CH:25][C:16]=1[CH:15]=[CH:14][C:10]1[CH:9]=[C:8]([OH:7])[CH:13]=[CH:12][CH:11]=1

참가 물질

3

반응물 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 544075821-(2-Methoxyethoxy)-methoxy-3-(2-quinolin-2-yl-vinyl)-benzene

생성물 1

HCID 48788413-(2-Quinolin-2-yl-vinyl)-phenol

반응 조건

온도
60 °C

실험 절차

To a solution of 1-(2-methoxyethoxy)-methoxy-3-(2-quinolin-2-yl-vinyl)-benzene (120 mg, 0.35 mmol, example 16) is added p-toluene sulphonic acid monohydrate. (74 mg, 0.39 mmol). The resulting solution is heated to 60° C. and stirred at this temperature for 4 h. The reaction mixture is then cooled, concentrated and the residue taken up in dichloromethane. This solution is washed with sat. NaHCO3 solution, dried over MgSO4 then concentrated to give the title compound as a solid. MS (ESI) 248 (M+H)+.

후처리

  1. temperatureThe reaction mixture is then cooled
  2. concentrationconcentrated
  3. washThis solution is washed with sat. NaHCO3 solution
  4. dry with materialdried over MgSO4
  5. concentrationthen concentrated

출처 및 근거

ORD 기록
ord-9e6fd853a2dc49e28aaf2c784df32eee
출처 데이터셋
uspto-grants-2006_02
특허 번호
US07005440B1

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