N-(5-Nitro-2-methoxyphenyl)-2,2,5-trimethyl-beta-oxo-1,3-dioxane-5-propanamide → N-(5-AMINO-2-METHOXYPHENYL)-2,2,5-TRIMETHYL-beta-OXO-1,3-DIOXANE-5-PROPANAMIDE

HRID 892404노트

반응식

HRID 892404 반응식
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([O:25][CH3:26])=[C:8]([NH:10][C:11](=[O:24])[CH2:12][C:13](=[O:23])[C:14]2([CH3:22])[CH2:19][O:18][C:17]([CH3:21])([CH3:20])[O:16][CH2:15]2)[CH:9]=1)([O-])=O>O1CCCC1.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([O:25][CH3:26])=[C:8]([NH:10][C:11](=[O:24])[CH2:12][C:13](=[O:23])[C:14]2([CH3:22])[CH2:19][O:18][C:17]([CH3:20])([CH3:21])[O:16][CH2:15]2)[CH:9]=1

참가 물질

4

반응물 1

HCID 19895265N-(5-Nitro-2-methoxyphenyl)-2,2,5-trimethyl-beta-oxo-1,3-dioxane-5-propanamide

생성물 1

HCID 53685390N-(5-AMINO-2-METHOXYPHENYL)-2,2,5-TRIMETHYL-beta-OXO-1,3-DIOXANE-5-PROPANAMIDE

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8028Tetrahydrofuran용매

실험 절차

N-(5-Nitro-2-methoxyphenyl)-2,2,5-trimethyl-β-oxo-1,3-dioxane-5-propanamide (22parts) are dissolved in dry tetrahydrofuran (250 parts) and placed in a Parr bottle. The nitro compound is hydrogenated at low pressure and at ambient conditions in a Parr apparatus over Pd-C catalyst (2.5 parts) for 3.5 hr. Thin layer chromatography is used to monitor reaction completion which appears to be quantitative with no other products except the desired amine. The reaction product is carried to the next synthesis without purification other than filtration to remove spent catalyst.

후처리

  1. customreaction completion which
  2. customThe reaction product is carried to the next synthesis without purification other than filtration
  3. customto remove

출처 및 근거

ORD 기록
ord-a80eaf050afc47a69fda9c2e28a7b3ba
출처 데이터셋
uspto-grants-1992_06
특허 번호
US05118599

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