Diethyl Ether → HCID 135537121, 화합물

HRID 892435노트

반응식

HRID 892435 반응식
Cl[C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[N:3]=1.[CH2:19]([NH2:21])[CH3:20].C(OCC)C>C(O)C>[CH2:19]([NH:21][C:2]1[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[NH:5][C:6](=[O:8])[CH:7]=1)[CH3:20]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 6341EthylamineHCID 178458304HCID 178458304, 화합물

생성물 1

HCID 135537121HCID 135537121, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4-Chloro-6-hydroxy-2-(2-propoxyphenyl)pyrimidine (0.66 g) and ethylamine in ethanol (33%, 20 ml) was heated at 90° C. in a pressure vessel for 16 hours. The cooled reaction mixture was evaporated under reduced pressure to yield an oil which solidified on trituration with diethyl ether. The residue was recrystallised from isopropanol: diethyl ether, washed with water and recrystallised from isopropanol:water to yield the title compound, 0.47 g, m.p. 187°-8° C.

후처리

  1. customThe cooled reaction mixture
  2. customwas evaporated under reduced pressure
  3. customto yield an oil which
  4. customThe residue was recrystallised from isopropanol
  5. washdiethyl ether, washed with water
  6. customrecrystallised from isopropanol

출처 및 근거

ORD 기록
ord-f17bc6c8a5b247e5bbd9ece180c9a8b2
출처 데이터셋
uspto-grants-1992_06
특허 번호
US05118686

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