6-[5-Cyano-2-hydroxy-alpha-(2-methylpropenyl)benzyl]pyrimidine 1-oxide → 6-(6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)pyrimidine 1-oxide

HRID 892582노트

반응식

HRID 892582 반응식
[C:1]([C:3]1[CH:4]=[CH:5][C:6]([OH:21])=[C:7]([CH:20]=1)[CH:8]([C:13]1[N+:18]([O-:19])=[CH:17][N:16]=[CH:15][CH:14]=1)[CH:9]=[C:10]([CH3:12])[CH3:11])#[N:2]>C(OCC)(=O)C.CCCCCC>[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:21][C:10]([CH3:12])([CH3:11])[CH2:9][CH:8]([C:13]3[N+:18]([O-:19])=[CH:17][N:16]=[CH:15][CH:14]=3)[C:7]=2[CH:20]=1)#[N:2]

참가 물질

3

반응물 1

HCID 198956626-[5-Cyano-2-hydroxy-alpha-(2-methylpropenyl)benzyl]pyrimidine 1-oxide

생성물 1

HCID 198956856-(6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)pyrimidine 1-oxide수율 4.5%

시약·촉매·용매 1

HCID 21226206Ethyl acetate hexane용매

실험 절차

In an analogous manner to that described in the first paragraph of Example 8, from 0.22 g of 6-[5-cyano-2-hydroxy-α-(2-methylpropenyl)benzyl]pyrimidine 1-oxide there was obtained 0.01 g of 6-(6-cyano-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-4-yl)pyrimidine 1-oxide in the form of an off-white solid (from ethyl acetate/n-hexane).

출처 및 근거

ORD 기록
ord-ff316a685cf846daac974acc0f73ff45
출처 데이터셋
uspto-grants-1992_06
특허 번호
US05118694

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