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Lithium hexamethyldisilazane → 2-(1-Methylethyl)-5,9,13-trimethyl-1-trimethylsiloxy-2,4,8,12-cyclotetradecatetraene-1-carbonitrile

HRID 892642
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HRID 892642 반응식
C[Si]([N-][Si](C)(C)C)(C)C.[Li+].Cl[CH2:12][C:13]([CH3:38])=[CH:14][CH2:15][CH2:16][C:17]([CH3:37])=[CH:18][CH2:19][CH2:20][C:21]([CH3:36])=[CH:22][CH:23]=[C:24]([CH:33]([CH3:35])[CH3:34])[CH:25]([O:28][Si:29]([CH3:32])([CH3:31])[CH3:30])[C:26]#[N:27]>O1CCCC1>[CH3:34][CH:33]([C:24]1[C:25]([O:28][Si:29]([CH3:32])([CH3:31])[CH3:30])([C:26]#[N:27])[CH2:12][C:13]([CH3:38])=[CH:14][CH2:15][CH2:16][C:17]([CH3:37])=[CH:18][CH2:19][CH2:20][C:21]([CH3:36])=[CH:22][CH:23]=1)[CH3:35].[CH3:35][CH:33]([C:24]1[C:25](=[O:28])[CH2:26][C:13]([CH3:38])=[CH:14][CH2:15][CH2:16][C:17]([CH3:37])=[CH:18][CH2:19][CH2:20][C:21]([CH3:36])=[CH:22][CH:23]=1)[CH3:34]
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참가 물질

5

반응물 2

HCID 2733832Lithium hexamethyldisilazaneHCID 53993800HCID 53993800, 화합물

생성물 2

HCID 544770112-(1-Methylethyl)-5,9,13-trimethyl-1-trimethylsiloxy-2,4,8,12-cyclotetradecatetraene-1-carbonitrile수율 83%HCID 570081642-(1-Methylethyl)-5,9,13-trimethyl-2,4,8,12-cyclotetradecatetraen-1-one수율 16%

시약·촉매·용매 1

HCID 8028
Tetrahydrofuran
용매
2회

실험 절차

A solution of lithium bis(trimethylsilyl) amide (5.0 mmol, 0.25 M) in dry tetrahydrofuran (20 ml) is stirred under argon atmosphere on an oil bath at 40° C. and thereto is dropwise added a solution of the cyanohydrin trimethylsilyl ether which is 15-chloro-3-(1-methylethyl)-6,10,14-tri-methyl-2-trimethylsiloxy-3,5,9,13-pentadecatetraenenitrile (378 mg, 0.895 mmol) prepared in Reference Example 5 in dry tetrahydrofuran (15 ml) over 50 minutes. After stirring the mixture at this temperature for 20 minutes, the reaction is quenched by adding a saturated aqueous ammonium chloride solution while stirring on an ice-water bath. After removing tetrahydrofuran by distillation under reduced pressure, the organic layer is extracted with ether. The obtained extract is purified by silica gel column chromatography (n-hexane/ethyl acetate =60:1) to give 2-(1-methylethyl)-5,9,13-trimethyl-1-trimethylsiloxy-2,4,8,12-cyclotetradecatetraene-1-carbonitrile (288 mg, 83%) and 2-(1-methylethyl)-5,9,13-trimethyl-2,4,8,12-cyclotetradeca-tetraen-1-on (42.9 mg, 16%).

후처리

  1. customthe reaction is quenched
  2. additionby adding a saturated aqueous ammonium chloride solution
  3. stirringwhile stirring on an ice-water bath
  4. customAfter removing tetrahydrofuran
  5. distillationby distillation under reduced pressure
  6. extractionthe organic layer is extracted with ether
  7. extractionThe obtained extract
  8. customis purified by silica gel column chromatography (n-hexane/ethyl acetate =60:1)

출처 및 근거

ORD 기록
ord-fe6ca8b7887141968dc6c3f5dec18cc9
출처 데이터셋
uspto-grants-1992_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05118827

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