Benzyl Bromide → 2-Benzyloxy-5-phenoxybenzaldehyde

HRID 892845노트

반응식

HRID 892845 반응식
[O:1]([C:8]1[CH:9]=[CH:10][C:11]([OH:16])=[C:12]([CH:15]=1)[CH:13]=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:23](Br)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CN(C=O)C.C(OCC)(=O)C>[CH2:23]([O:16][C:11]1[CH:10]=[CH:9][C:8]([O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:15][C:12]=1[CH:13]=[O:14])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

참가 물질

6

반응물 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 149712582-Hydroxy-5-phenoxybenzaldehyde

생성물 1

HCID 104477522-Benzyloxy-5-phenoxybenzaldehyde

시약·촉매·용매 2

HCID 6228Dimethylformamide용매HCID 8857Ethyl Acetate용매

실험 절차

5-Phenoxy-2-hydroxybenzaldehyde (20 g, 94 mmol) and potassium carbonate (26.1 g, 188 mmol) are taken up in DMF (250 mL) and treated with benzyl bromide (16.1 g, 94 mmol). The mixture is stirred at room temperature overnight. The mixture is diluted with ethyl acetate and washed three times with saturated aqueous ammonium chloride, dried over magnesium sulfate and evaporated to give 2-benzyloxy-5-phenoxybenzaldehyde as a colorless solid. This is used without further purification.

후처리

  1. washwashed three times with saturated aqueous ammonium chloride
  2. dry with materialdried over magnesium sulfate
  3. customevaporated

출처 및 근거

ORD 기록
ord-8867b9d0b3334aae9bbc167c1acc113c
출처 데이터셋
uspto-grants-1992_06
특허 번호
US05120758

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