Hydrogen Peroxide → 2-Benzyloxy-5-phenoxyphenol

HRID 892846노트

반응식

HRID 892846 반응식
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:14]([O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:13][C:10]=1C=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.OO.S(=O)(=O)(O)[OH:27]>CO>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:14]([O:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)=[CH:13][C:10]=1[OH:27])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 784Hydrogen PeroxideHCID 1118Sulfuric AcidHCID 104477522-Benzyloxy-5-phenoxybenzaldehyde

생성물 1

HCID 152014472-Benzyloxy-5-phenoxyphenol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

2-Benzyloxy-5-phenoxybenzaldehyde (22.25 g, 73 mmol) is dissolved in methanol (200 mL) and treated with hydrogen peroxide (31% in water, 32.0 mL) and concentrated sulfuric acid (15.0 mL). The mixture is stirred overnight at room temperature and evaporated. The residue is dissolved in saturated aqueous sodium chloride solution and extracted with ether. The organic phase is dried over magnesium sulfate and evaporated. Purification of the residue by silica-gel flash chromatography gives 2-benzyloxy-5-phenoxyphenol as a colorless solid.

후처리

  1. customevaporated
  2. dissolutionThe residue is dissolved in saturated aqueous sodium chloride solution
  3. extractionextracted with ether
  4. dry with materialThe organic phase is dried over magnesium sulfate
  5. customevaporated
  6. customPurification of the residue by silica-gel flash chromatography

출처 및 근거

ORD 기록
ord-7f3d9d13f8b94dafb22414c9a40c28e8
출처 데이터셋
uspto-grants-1992_06
특허 번호
US05120758

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