4-Aminophenol → 2,4-Diacetoxy-N-[3-[(4-hydroxyphenyl)amino]-3-oxopropyl]-3,3-dimethylbutanamide

HRID 892879노트

반응식

HRID 892879 반응식
C(N=C=NCCCN(C)C)C.[C:12]([O:15][CH:16]([C:25]([CH3:32])([CH3:31])[CH2:26][O:27][C:28](=[O:30])[CH3:29])[C:17]([NH:19][CH2:20][CH2:21][C:22]([OH:24])=O)=[O:18])(=[O:14])[CH3:13].[CH:33]1[C:38]([NH2:39])=[CH:37][CH:36]=[C:35]([OH:40])[CH:34]=1>C(Cl)Cl>[C:12]([O:15][CH:16]([C:25]([CH3:32])([CH3:31])[CH2:26][O:27][C:28](=[O:30])[CH3:29])[C:17]([NH:19][CH2:20][CH2:21][C:22]([NH:39][C:38]1[CH:33]=[CH:34][C:35]([OH:40])=[CH:36][CH:37]=1)=[O:24])=[O:18])(=[O:14])[CH3:13]

참가 물질

5

반응물 3

HCID 4034-AminophenolHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 19893582HCID 19893582, 화합물

생성물 1

HCID 198936262,4-Diacetoxy-N-[3-[(4-hydroxyphenyl)amino]-3-oxopropyl]-3,3-dimethylbutanamide수율 50%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (2.30 g) was added to a solution of 3.03 g of 3-[N-(2,4-diacetoxy-3,3-dimethyl-1-oxobutyl)amino]propionic acid and 2.18 g of p-aminophenol in 50 ml of methylene chloride, and the mixture was stirred for one night. After completion of the reaction, the reaction mixture was washed with water, and dried over anhydrous sodium sulfate. After removing the solvent by evaporation, the residue obtained was purified by silica gel column chromatography to obtain 1.92 g of the objective compound was obtained as a residue (yield: 50%).

후처리

  1. customAfter completion of the reaction
  2. washthe reaction mixture was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customAfter removing the solvent
  5. customby evaporation
  6. customthe residue obtained
  7. customwas purified by silica gel column chromatography

출처 및 근거

ORD 기록
ord-29ebae54edf34cfdbcc7eb7763d0fa8a
출처 데이터셋
uspto-grants-1992_06
특허 번호
US05120738

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