Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → Diisopropylethylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | N,N,N',N'-Tetramethylethylenediamine | HCID 8037 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Diethylmethylamine | HCID 12022 | — |
| 생성물 | Diisopropylethylamine | HCID 81531 | — |
반응 단계
Surprisingly, diisopropylethylamine in methylene chloride gave a 59:41 mixture of starting material:2-iodo product (Run #14), and only a trace of the 2-iodo product was observed in toluene under similar conditions. The low solubility of the hydrohalide salts of TMEDA, Et3N and Et2MeN in the above solvents may be responsible for their usefulness as opposed to the poor results with diisopropylethylamine. Precipitation of these hydrohalide salts may remove sufficient acid from the reaction so that the equilibrium is displaced toward product allowing the reaction to proceed to completion.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05120847 |
| 출처 데이터셋 | uspto-grants-1992_06 |
| ORD ID | ord-ee7ecbde496a44018511101be93ab07d |
| 출처 메모 | uspto-grants-1992_06 |