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Potassium Carbonate → N-(2-butenyl)-N-(4-chloro-3-isopropylphenyl)-2-chloro-2-(3-fluorophenyl)acetamide

HRID 893187
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HRID 893187 반응식
[Cl:1][CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=1)[C:3](Cl)=[O:4].[CH2:13]([NH:17][C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([CH:25]([CH3:27])[CH3:26])[CH:19]=1)[CH:14]=[CH:15][CH3:16].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:13]([N:17]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([CH:25]([CH3:27])[CH3:26])[CH:19]=1)[C:3](=[O:4])[CH:2]([Cl:1])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=1)[CH:14]=[CH:15][CH3:16]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 198914902-Chloro-2-(3-fluorophenyl)acetyl chlorideHCID 54500563N-(2-butenyl)-N-(4-chloro-3-isopropylphenyl)amine

생성물 1

HCID 54355070N-(2-butenyl)-N-(4-chloro-3-isopropylphenyl)-2-chloro-2-(3-fluorophenyl)acetamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

2.6 g of 2-chloro-2-(3-fluorophenyl)acetyl chloride were gradually added dropwise to 2.2 g of N-(2-butenyl)-N-(4-chloro-3-isopropylphenyl)amine and 2.0 g of anhydrous potassium carbonate in 40 ml of N,N-dimethylformamide with stirring at 20°-30° C. After the stirring was additionally continued for 20 minutes, potassium carbonate was removed by filtration, and extraction was then carried out with toluene. After drying over anhydrous sodium sulfate, the reaction solution was concentrated by means of an evaporator to quantitatively obtain the desired oily product.

후처리

  1. custompotassium carbonate was removed by filtration, and extraction
  2. dry with materialAfter drying over anhydrous sodium sulfate
  3. concentrationthe reaction solution was concentrated by means of an evaporator
  4. customto quantitatively obtain the desired oily product

출처 및 근거

ORD 기록
ord-211ba34586764a49a4b4afa93feb9e93
출처 데이터셋
uspto-grants-1992_06
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05123954

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