Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → N-[2-(3-methyl-4-methoxyphenyl)ethyl]-3-(4-chlorophenyl)propionamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | beta-(p-Chlorophenyl)propionic acid | HCID 123137 | — |
| 반응물 | 2-(4-Methoxy-3-methylphenyl)ethan-1-amine | HCID 6484660 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | N-[2-(3-methyl-4-methoxyphenyl)ethyl]-3-(4-chlorophenyl)propionamide | HCID 19892235 | 80.1% |
반응 단계
Heat a solution of 2-(3-methyl-4-methoxyphenyl)ethylamine (64.4 g) and 3-(4-chlorophenyl)-propionic acid (70.2 g) in xylene (600 mL) at reflux over a Dean-Stark trap for 5.5 h. Pour the hot reaction mixture into water an allow to stand overnight. Filter to collect the solid and recrystallize from ethanol to give N-[2-(3-methyl-4-methoxyphenyl)ethyl]-3-(4-chlorophenyl)propionamide (101.1 g), mp=142°-144° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05124337 |
| 출처 데이터셋 | uspto-grants-1992_06 |
| ORD ID | ord-d59382d05ed643019d118244af46137a |
| 출처 메모 | uspto-grants-1992_06 |