Acetic Acid → Diisopropylether methanol

HRID 893343

반응식

HRID 893343 반응식
CC1C=C2[C:8](=[CH:9][CH:10]=1)N[C:6](=[O:11])C2.[CH3:12][C:13]([O-:15])=O.[Na+].[C:17](O)(=O)C>>[CH3:6][OH:11].[O:15]([CH:9]([CH3:8])[CH3:10])[CH:13]([CH3:12])[CH3:17]

참가 물질

4

반응물 3

HCID 176Acetic AcidHCID 517045Sodium AcetateHCID 53257165-Methylindolin-2-one

생성물 1

HCID 21882575Diisopropylether methanol

실험 절차

A mixture of 5-methyl-2-oxindole (2.94 g, 0.02 mol), 3,5-di-tertiary-butyl-4-hydroxybenzoldehyde (4.68 g, 0.02 mol), and anyydrous NaOAc (5.75 g, 0.07 mol) in glacial acetic acid (100 mL) was heated to reflux for 18 hours. The cooled reaction mixture was poured into ice-water mixture when a yellow product precipitated out. It was recrystallized from CH2Cl2 --CH3OH-iso-Pr2O to give the analytical sample. Yield 2.16 g (28.7%), mp 230°-234° C.

후처리

  1. temperaturewas heated
  2. temperatureto reflux for 18 hours
  3. customThe cooled reaction mixture
  4. customprecipitated out
  5. customIt was recrystallized from CH2Cl2

출처 및 근거

ORD 기록
ord-9e9feb137dcb4903abe56920c948ff41
출처 데이터셋
uspto-grants-1992_06
특허 번호
US05124347

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