Triethylamine → D-Galactosamine

HRID 893382

반응식

HRID 893382 반응식
Cl.[OH:2][CH:3]1[O:11][C@H:10]([CH2:12][OH:13])[C@H:8]([OH:9])[C@H:6]([OH:7])[C@H:4]1[NH2:5].C(N(CC)CC)C>CN(C=O)C>[OH:2][CH:3]1[O:11][C@H:10]([CH2:12][OH:13])[C@H:8]([OH:9])[C@H:6]([OH:7])[C@H:4]1[NH2:5]

참가 물질

4

반응물 2

HCID 8471Triethylamine2회HCID 2723866D-(+)-Galactosamine hydrochloride

생성물 1

HCID 24154D-Galactosamine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

In 10 ml of DMF was dissolved 0.22 g of galactosamine hydrochloride (1.04×10-3 mol). After 0.15 ml (1.04×10-3 mol) of triethylamine was added to the solution, 0.30 g (1.84×10-3 mol, value calculated from apparent molecular weight per 1 unit) was added to the mixture. The reaction was carried out at room temperature for 2 days. Then the solution containing the precipitates was dialyzed (2 days) and then freeze dried to prepare a sample (charged amounts given herein are for the sample obtained by activation of the side chain using the polymer having a side chain hydrolysis rate of 28.6% described above. For other samples, about two-fold amounts of sugar and triethylamine were used in response to the rate of activation of the side chain).

후처리

  1. additionwas added to the mixture
  2. additionThen the solution containing the precipitates
  3. customwas dialyzed (2 days)
  4. customfreeze dried
  5. customto prepare a sample (
  6. additioncharged amounts
  7. customobtained by activation of the side chain
  8. customa side chain hydrolysis rate of 28.6%

출처 및 근거

ORD 기록
ord-489831f9d3074d59b89e707cb5479ecc
출처 데이터셋
uspto-grants-1992_06
특허 번호
US05124437

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