tert-butyl N-(2-oxoethyl)carbamate → N'-(4-{[(1H-Benzimidazol-2-ylmethyl)-(5,6,7,8-tetrahydro-quinolin-8-yl)-amino]-methyl}-benzyl)-ethane-1,2-diamine

참여 물질

역할	이름	HCID	투입량
반응물	tert-butyl N-(2-oxoethyl)carbamate	HCID 4247255	—
반응물	Sodium triacetoxyborohydride	HCID 5049666	—
반응물	N-[(1H-Benzo[d]imidazol-2-yl)methyl]-N-(4-(aminomethyl)-benzyl)-5,6,7,8-tetrahydroquinolin-8-amine	HCID 21985008	—
용매	Tetrahydrofuran	HCID 8028	—
생성물	N'-(4-{[(1H-Benzimidazol-2-ylmethyl)-(5,6,7,8-tetrahydro-quinolin-8-yl)-amino]-methyl}-benzyl)-ethane-1,2-diamine	HCID 21985114	17%

반응 단계

Using General Procedure B: To a stirred solution of N′-(1H-benzimidazol-2-ylmethyl)-N′-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine (250 mg, 0.629 mmol) and (2-oxo-ethyl)-carbamic acid tert-butyl ester (100 mg, 0.628 mmol) in THF (6.3 mL) was added NaBH(OAc)3 (173 mg, 0.816 mmol) and the mixture was stirred at room temperature for 22 h. Purification of the crude material by column chromatography on silica gel (200:5:1 CH2Cl2/MeOH/NH4OH) afforded a colourless oil (47 mg).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07091217B2
출처 데이터셋	uspto-grants-2006_08
ORD ID	ord-46852be027304803a1cc633363f06368
출처 메모	uspto-grants-2006_08