Hydrogen Peroxide → 5-Ethynyl-1-pentofuranosyl-1H-imidazole-4-carboximidic acid

HRID 893706노트

반응식

HRID 893706 반응식
[C:1]([C:3]1[N:7]([C@@H:8]2[O:14][C@H:13]([CH2:15][OH:16])[C@@H:11]([OH:12])[C@H:9]2[OH:10])[CH:6]=[N:5][C:4]=1[C:17]#[N:18])#[CH:2].[OH:19]O>N.CO>[C:1]([C:3]1[N:7]([C@@H:8]2[O:14][C@H:13]([CH2:15][OH:16])[C@@H:11]([OH:12])[C@H:9]2[OH:10])[CH:6]=[N:5][C:4]=1[C:17]([NH2:18])=[O:19])#[CH:2]

참가 물질

5

반응물 2

HCID 784Hydrogen PeroxideHCID 11043123HCID 11043123, 화합물

생성물 1

HCID 4531805-Ethynyl-1-pentofuranosyl-1H-imidazole-4-carboximidic acid

시약·촉매·용매 2

HCID 222Ammonia용매HCID 887Methanol용매

실험 절차

To a solution of 127 mg (0.51 mmol) of 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carbonitrile dissolved in 6 ml of a solvent mixture of aqueous ammonia and methanol (1:1) was added 0.5 ml of hydrogen peroxide, and the reaction was carried out with stirring at room temperature for 45 minutes. After the reaction, the solvent was evaporated, and the residue was adsorbed onto a silica gel column and eluted with a 5 - 10% ethanolchloroform solvent mixture, and crystallized from ethanol to obtain white crystals of 5-ethynyl-1-β-D-ribofuranosylimidazole-4-carboxamide.

후처리

  1. customAfter the reaction
  2. customthe solvent was evaporated
  3. washeluted with a 5 - 10% ethanolchloroform solvent mixture
  4. customcrystallized from ethanol

출처 및 근거

ORD 기록
ord-1a8a7ec297a44b34a09c6d4c8223575f
출처 데이터셋
uspto-grants-1992_06
특허 번호
US05126361

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