Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl chloroformate → 4-(2,3,4-Trimethoxybenzylthio)-1-cinnamylpiperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl chloroformate | HCID 10928 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Toluene, alpha-chloro-2,3,4-trimethoxy- | HCID 97491 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 반응물 | Fumarate | HCID 5460307 | — |
| 반응물 | 1-Methylpiperidine-4-thiol | HCID 14180391 | — |
| 반응물 | 4-(2,3,4-Trimethoxybenzylthio)-1-ethoxycarbonylpiperidine | HCID 19890907 | — |
| 반응물 | 4-(2,3,4-Trimethoxybenzylthio)-1-cinnamylpiperidine fumarate | HCID 67894540 | — |
| 용매 | Benzene | HCID 241 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 4-(2,3,4-Trimethoxybenzylthio)-1-cinnamylpiperidine | HCID 53752093 | — |
반응 단계
The 4-(2,3,4-trimethoxybenzylthio)piperidine used as starting material, the fumarate of which melts at 154° C., was prepared by the hydrolysis, using potassium hydroxide and ethanol, of 4-(2,3,4-trimethoxybenzylthio)-1-ethoxycarbonylpiperidine (oil), which was itself prepared by the action of ClCOOC2H5 in benzene on 4-(2,3,4-trimethoxybenzylthio)-1-methylpiperidine (m.p. of the corresponding fumarate: 130° C.), which was itself prepared by the condensation of 2,3,4-trimethoxybenzyl chloride in ethanol with the sodium salt of 1-methyl-4-mercaptopiperidine, b.p./13 : 70°-72° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05126356 |
| 출처 데이터셋 | uspto-grants-1992_06 |
| ORD ID | ord-723d3b8048ee46d3b6b86ab349d9e5a4 |
| 출처 메모 | uspto-grants-1992_06 |