Acrylonitrile → 9-(2-Cyanoethyl)-9H-fluorene-9-carboxamide

HRID 893918

반응식

HRID 893918 반응식
[C:1]([CH:4]1[C:16]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:10]2[C:5]1=[CH:6][CH:7]=[CH:8][CH:9]=2)(=[O:3])[NH2:2].[C:17](#[N:20])[CH:18]=[CH2:19]>O1CCCC1>[C:1]([C:4]1([CH2:19][CH2:18][C:17]#[N:20])[C:16]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:10]2[C:5]1=[CH:6][CH:7]=[CH:8][CH:9]=2)(=[O:3])[NH2:2]

참가 물질

4

반응물 2

HCID 7855AcrylonitrileHCID 3450289H-fluorene-9-carboxamide

생성물 1

HCID 30188199-(2-Cyanoethyl)-9H-fluorene-9-carboxamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

One hundred g. of 9-carbamoylfluorene was slurried in 3375 ml. of tetrahydrofuran in a 5-liter flask. The mixture was heated to 45° with stirring, and to it was added 10 ml. of Triton B. The mixture was stirred for 15 minutes at constant temperature, and 26.2 g. of acrylonitrile was then added in one portion. The mixture was stirred at the reflux temperature for 3 hours, and was then allowed to cool to room temperature. The mixture was then concentrated under vacuum to a solid, which was purified as described in Example 1 above to obtain 110 g. of product, analytically identical to the product of Example 1.

후처리

  1. temperatureThe mixture was heated to 45°
  2. additionto it was added 10 ml
  3. stirringThe mixture was stirred for 15 minutes at constant temperature, and 26.2 g
  4. stirringThe mixture was stirred at the reflux temperature for 3 hours
  5. concentrationThe mixture was then concentrated under vacuum to a solid, which
  6. customwas purified
  7. customto obtain 110 g

출처 및 근거

ORD 기록
ord-a78c83178ab34b7db593c36258dfff98
출처 데이터셋
uspto-grants-1981_08
특허 번호
US04282170

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