Aziridine-2-carbonitrile → HCID 21161947, 화합물
반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([N:8]=[C:9]=[O:10])=[O:7].[C:11]([CH:13]1[CH2:15][NH:14]1)#[N:12]>C1(C)C=CC=CC=1>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]([NH:8][C:9]([N:14]1[CH2:15][CH:13]1[C:11]#[N:12])=[O:10])=[O:7]참가 물질
4
실험 절차
2.76 g. Thiophene-2-carbonyl isocyanate are dissolved in 45 ml. anhydrous toluene and mixed dropwise, while stirring, at 20° to 30° C. with a solution of 1.22 g. 2-cyanoaziridine in 30 ml. toluene. Stirring is continued for 1 hour at ambient temperature and the precipitate obtained is filtered off with suction, washed with toluene and subsequently triturated with diethyl ether. There are thus obtained 3.4 g. 1-(N-2-thiophene-carbonyl-carbamoyl)-2-cyanoaziridine; m.p. 156°-160° C., which still contains a little thiophene-2-carboxylic acid amide.
후처리
- stirringStirring
- customthe precipitate obtained
- filtrationis filtered off with suction
- washwashed with toluene
- customsubsequently triturated with diethyl ether
출처 및 근거
- ORD 기록
- ord-86125920b2814ee88f415d6ae0b6b6b5
- 출처 데이터셋
- uspto-grants-1981_08
- 특허 번호
- US04282212
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