3-Allyl-4-methyl-4,5-epoxypentan-2-one → 2,4-Dimethyl-3-(prop-2-en-1-yl)furan

HRID 894157노트

반응식

HRID 894157 반응식
[CH2:1]([CH:4]([C:8]1([CH3:11])[O:10][CH2:9]1)[C:5](=O)[CH3:6])[CH:2]=[CH2:3]>C(=O)([O-])[O-].[Na+].[Na+]>[CH3:11][C:8]1[O:10][CH:9]=[C:5]([CH3:6])[C:4]=1[CH2:1][CH:2]=[CH2:3]

참가 물질

3

반응물 1

HCID 132086283-Allyl-4-methyl-4,5-epoxypentan-2-one

생성물 1

HCID 132086342,4-Dimethyl-3-(prop-2-en-1-yl)furan수율 45.3%

시약·촉매·용매 1

HCID 10340Sodium Carbonate용매

실험 절차

3-Allyl-4-methyl-4,5-epoxy-pentan-2-one (4.50 g) was added to a 1% aqueous sodium carbonate solution (150 ml), followed by stirring for 2 hours at a bath temperature of 60° to 65° C. The reaction solution was extracted three times with methylene chloride, and the methylene chloride layer was washed with an aqueous sodium chloride solution. After removing the solvent by evaporation, the residue was column chromatographed on silica gel (50 g) and developed with methylene chloride. From the first eluate (400 ml) was obtained 1.80 g of a pure objective 2,4-dimethyl-3-allylfuran.

후처리

  1. extractionThe reaction solution was extracted three times with methylene chloride
  2. washthe methylene chloride layer was washed with an aqueous sodium chloride solution
  3. customAfter removing the solvent
  4. customby evaporation
  5. customchromatographed on silica gel (50 g)

출처 및 근거

ORD 기록
ord-6e38610a068c406181689ecfda0b98dd
출처 데이터셋
uspto-grants-1981_08
특허 번호
US04282372

반응 노트

불러오는 중…