Sodium Cyanide → 9-Cyanomethyl-6,11-dihydro-11-oxodibenz[b,e]oxepin
반응식
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][O:11][C:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=3[C:8](=[O:17])[C:7]=2[CH:18]=1.[C-:19]#[N:20].[Na+]>CN(C)C=O.O>[C:19]([CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][O:11][C:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]=3[C:8](=[O:17])[C:7]=2[CH:18]=1)#[N:20]참가 물질
5
실험 절차
Dissolve 6.4 gm of the bromomethyl compound of Step C in 75 cc of dimethylformamide and add 2.95 gm of sodium cyanide. Stir the mixture at room temperature for 1.5 hours. Dilute with 600 cc of water and extract three times with ether. Wash the combined organics with water, dry and strip to a solid residue. Triturate in hexane and recover the solid by filtration.
후처리
- extractionextract three times with ether
- washWash the combined organics with water
- customdry
- customTriturate in hexane
- customrecover the solid
- filtrationby filtration
출처 및 근거
- ORD 기록
- ord-f2ceabd323ad4e6ab2fdf14891ece8fc
- 출처 데이터셋
- uspto-grants-1981_08
- 특허 번호
- US04282365
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