Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Tetrahydrofuran → 6,11-Dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Methyl 11-hydroxy-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylate | HCID 2769059 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 6,11-Dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylic Acid | HCID 12929144 | — |
반응 단계
Dissolve 900 mg. of methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylate in 20 cc. of tetrahydrofuran. Add 20 cc. 1 N aqueous sodium hydroxide. Stir at room temperature for 48 hours. Dilute with water and extract with ether. Acidify the aqueous fraction with hydrochloric acid and extract with ether. Evaporate the organic phase to obtain the title product (m.p. 275° C. dec.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04282365 |
| 출처 데이터셋 | uspto-grants-1981_08 |
| ORD ID | ord-06261300041049b7ae1e5f982962a19a |
| 출처 메모 | uspto-grants-1981_08 |