Tetrahydrofuran → 6,11-Dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylic Acid

HRID 894200

반응식

HRID 894200 반응식
[OH:1][CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][O:5][C:4]2[CH:13]=[CH:14][C:15]([C:17]([O:19]C)=[O:18])=[CH:16][C:3]1=2.O1CCCC1.[OH-].[Na+]>O>[OH:1][CH:2]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH2:6][O:5][C:4]2[CH:13]=[CH:14][C:15]([C:17]([OH:19])=[O:18])=[CH:16][C:3]1=2

참가 물질

5

반응물 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 2769059Methyl 11-hydroxy-6,11-dihydrobenzo[c][1]benzoxepine-2-carboxylate

생성물 1

HCID 129291446,11-Dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylic Acid

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Dissolve 900 mg. of methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylate in 20 cc. of tetrahydrofuran. Add 20 cc. 1 N aqueous sodium hydroxide. Stir at room temperature for 48 hours. Dilute with water and extract with ether. Acidify the aqueous fraction with hydrochloric acid and extract with ether. Evaporate the organic phase to obtain the title product (m.p. 275° C. dec.).

후처리

  1. dissolutionDissolve 900 mg
  2. additionAdd 20 cc
  3. extractionextract with ether
  4. extractionextract with ether
  5. customEvaporate the organic phase

출처 및 근거

ORD 기록
ord-06261300041049b7ae1e5f982962a19a
출처 데이터셋
uspto-grants-1981_08
특허 번호
US04282365

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