alpha-Fluoro-3-phenoxybenzylbromide → alpha-Fluoro-3-phenoxybenzyl alpha-isopropyl-(3,4-dichlorophenyl)acetate

HRID 894343노트

반응식

HRID 894343 반응식
[CH:1]([CH:4]([C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=1)[C:5]([OH:7])=[O:6])([CH3:3])[CH3:2].[F:16][CH:17](Br)[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:19]=1>>[CH:1]([CH:4]([C:8]1[CH:13]=[CH:12][C:11]([Cl:14])=[C:10]([Cl:15])[CH:9]=1)[C:5]([O:7][CH:17]([F:16])[C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([O:24][C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:19]=1)=[O:6])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 13194583alpha-Fluoro-3-phenoxybenzylbromideHCID 205073302-(3,4-Dichlorophenyl)-3-methylbutanoic acid

생성물 1

HCID 53806714alpha-Fluoro-3-phenoxybenzyl alpha-isopropyl-(3,4-dichlorophenyl)acetate

실험 절차

This compound was prepared from α-isopropyl-(3,4-dichlorophenyl)acetic acid and α-fluoro-3-phenoxybenzyl bromide following the procedure described in Example 2 Method B. The product, a colourless oil, was characterised by pmr spectroscopy. Chemical shift δ ppm (solvent CDCl3): 0.76(3H, d, J=6Hz, CH3); 1.07(3H, d of d, J=6Hz and J=2Hz, CH3); 2.33(1H, m, --CH(CH3)2); 3.28(1H, d, J=10Hz, CH); 7.24(1H, d of d, J=56Hz and J=2Hz, CHF) and about 7.33(12H, m, aromatic protons).

출처 및 근거

ORD 기록
ord-8dcb370ba4d047609536e90909360921
출처 데이터셋
uspto-grants-1981_08
특허 번호
US04283414

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