Piperidine → Fenpropidin

HRID 894379

반응식

HRID 894379 반응식
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([CH3:15])[CH2:13]O)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>[Pd].CO>[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([CH3:15])[CH2:13][N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

5

반응물 2

HCID 8082PiperidineHCID 92013Benzenepropanol, 4-(1,1-dimethylethyl)-beta-methyl-

생성물 1

HCID 91694Fenpropidin수율 94%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 153 parts of 3-p-tertiary butylphenyl-2-methyl-propanol, 70 parts of piperidine, 230 parts of methanol and 20 parts of catalyst, comprising 0.5% by weight of Pd and 5% by weight of Nd2O3 on Al2O3, is hydrogenated in a stirred autoclave of 1,000 parts by volume capacity, at 70° C. under a hydrogen pressure of 50 bar, until the pressure remains constant. The autoclave is then allowed to cool, the catalyst is filtered off and the filtrate is purified by distillation. 195 parts of N-(3'-(p-tertiary butylphenyl)-2'-methylpropyl)-piperidine, boiling point 117° C./0.2 mm Hg, are obtained. The yield is 94% of theory.

후처리

  1. customis hydrogenated in a stirred autoclave of 1,000 parts by volume capacity, at 70° C. under a hydrogen
  2. temperatureto cool
  3. filtrationthe catalyst is filtered off
  4. distillationthe filtrate is purified by distillation

출처 및 근거

ORD 기록
ord-6cac709ee57a40e2a5318f5e20149460
출처 데이터셋
uspto-grants-1981_08
특허 번호
US04283534

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