Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(Dimethylamino)Benzaldehyde → 2,2-Dimethyl-3alpha-cyano-6alpha-(p-dimethylamino-alpha-hydroxybenzyl)penam
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(Dimethylamino)Benzaldehyde | HCID 7479 | — |
| 반응물 | 2,2-Dimethyl-3alpha-cyano-6alpha-bromopenam | HCID 12944713 | — |
| 촉매 | Zinc | HCID 23994 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 2,2-Dimethyl-3alpha-cyano-6alpha-(p-dimethylamino-alpha-hydroxybenzyl)penam | HCID 70545653 | — |
| 생성물 | 2,2-Dimethyl-3alpha-cyano-6beta-(p-dimethylamino-alpha-hydroxybenzyl)penam | HCID 70546902 | — |
반응 단계
A solution of 100 mg 2,2-dimethyl-3α-cyano-6α-bromopenam in 40 ml dry tetrahydrofuran is stirred with 60 mg p-dimethylaminobenzaldehyde and 500 mg zinc for about 12 hours at room temperature. The reaction mixture is then diluted in ethyl acetate, washed with aqueous sodium chloride and dried over anhydrous sodium sulfate. Chromatography of the mixture on silica gel affords, in 11:1 ratio, 2,2-dimethyl-3α-cyano-6α-(p-dimethylamino-α-hydroxybenzyl)penam and 2,2-dimethyl-3α-cyano-6β-(p-dimethylamino-α-hydroxybenzyl)penam. The 6α-compound has the following formula: ##STR39##
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04283531 |
| 출처 데이터셋 | uspto-grants-1981_08 |
| ORD ID | ord-778f6392483544c6bae51ae7e02cf154 |
| 출처 메모 | uspto-grants-1981_08 |