Thionyl Chloride → 2-(4-Difluoromethoxyphenyl)-3-methylbutyryl chloride

반응식

[F:1][CH:2]([F:17])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH:14]([CH3:16])[CH3:15])[C:11](O)=[O:12])=[CH:6][CH:5]=1.S(Cl)([Cl:20])=O>>[F:1][CH:2]([F:17])[O:3][C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH:14]([CH3:16])[CH3:15])[C:11]([Cl:20])=[O:12])=[CH:6][CH:5]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 131185654-(Difluoromethoxy)-alpha-(1-methylethyl)benzeneacetic acid

생성물 1

HCID 131185672-(4-Difluoromethoxyphenyl)-3-methylbutyryl chloride

실험 절차

20 g of 4-difluoromethoxy-α-isopropyl-phenylacetic acid were dissolved in 100 ml of thionyl chloride and the solution was heated to the boil for 1 hour. After distilling off excess thionyl chloride, the residue was distilled under a high vacuum. 4-Difluoromethoxy-α-isopropylphenylacetic acid chloride of boiling point 93°-99° C./0.2 mm Hg was obtained.

후처리

temperaturethe solution was heated to the boil for 1 hour
distillationAfter distilling off excess thionyl chloride
distillationthe residue was distilled under a high vacuum

출처 및 근거

ORD 기록: ord-93f8beaeda1141e0b7058b97dd4003b2
출처 데이터셋: uspto-grants-1981_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04284643

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