3-(Trifluoromethyl)aniline → HCID 20512399, 화합물

반응식

Cl[CH:2]([CH3:15])[CH2:3][NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[CH:6]=1.[F:16][C:17]([F:26])([F:25])[C:18]1[CH:19]=[C:20]([CH:22]=[CH:23][CH:24]=1)[NH2:21]>>[F:12][C:11]([F:14])([F:13])[C:7]1[CH:6]=[C:5]([NH:4][CH2:3][CH:2]([NH:21][C:20]2[CH:22]=[CH:23][CH:24]=[C:18]([C:17]([F:16])([F:25])[F:26])[CH:19]=2)[CH3:15])[CH:10]=[CH:9][CH:8]=1

참가 물질

반응물 2

HCID 73753-(Trifluoromethyl)aniline

HCID 20512435HCID 20512435, 화합물

생성물 1

HCID 20512399HCID 20512399, 화합물수율 76.6%

실험 절차

N-(β-chloropropyl)-3-trifluoromethyl-aniline is reacted with 3-trifluoromethylaniline as described in Example 16, point (c) to obtain 1,2-bis(3'-trifluoromethylphenyl-amino)propane with a yield of 76.6%. The dihydrochloride of this base melts at 116°-120° C.

출처 및 근거

ORD 기록: ord-474b3d04c5894499afc040e8c0a07c76
출처 데이터셋: uspto-grants-1981_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04284642

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