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Sodium Bicarbonate → 4-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]-2-butanol

HRID 894906
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HRID 894906 반응식
C([O:8][C:9]1[CH:14]=[C:13]([C:15]([CH3:23])([CH3:22])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[CH:12]=[CH:11][C:10]=1[CH2:24][CH2:25][CH:26]([OH:28])[CH3:27])C1C=CC=CC=1.C(=O)(O)[O-].[Na+].[H][H]>[Pd].C(O)C>[CH3:23][C:15]([C:13]1[CH:12]=[CH:11][C:10]([CH2:24][CH2:25][CH:26]([OH:28])[CH3:27])=[C:9]([OH:8])[CH:14]=1)([CH3:22])[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH3:21]
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참가 물질

6

반응물 3

HCID 516892Sodium BicarbonateHCID 205179964-[2-Benzyloxy-4-(1,1-dimethylheptyl)phenyl]-2-butanolHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 205179974-[4-(1,1-Dimethylheptyl)-2-hydroxyphenyl]-2-butanol

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol
용매

실험 절차

A mixture of 390 mg. (1.02 mmols.) of 4-[2-benzyloxy-4-(1,1-dimethylheptyl)phenyl]-2-butanol, 360 mg. of solid sodium bicarbonate, 100 mg. of 10% palladium-on-carbon and 10 ml. of ethanol is stirred under one atmosphere of hydrogen for 20 minutes. The reaction mixture is filtered through diatomaceous earth with ethyl acetate and evaporated to an oil. The oil is purified via rapid column chromatography on silica gel eluted with ether to give a quantitative yield of the title compound as an oil.

후처리

  1. additionA mixture of 390 mg
  2. filtrationThe reaction mixture is filtered through diatomaceous earth with ethyl acetate
  3. customevaporated to an oil
  4. customThe oil is purified via rapid column chromatography on silica gel
  5. washeluted with ether

출처 및 근거

ORD 기록
ord-878c3eb4a9ba42e28aee5ab49987adb9
출처 데이터셋
uspto-grants-1981_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04284829

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