Thionyl Chloride → 6,7-Dihydroxy-4-oxo-4H-1-benzopyran-3-carbonyl chloride

HRID 894982노트

반응식

HRID 894982 반응식
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[O:8][CH:7]=[C:6]([C:13](O)=[O:14])[C:5]2=[O:16].S(Cl)([Cl:19])=O>>[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[OH:12])[O:8][CH:7]=[C:6]([C:13]([Cl:19])=[O:14])[C:5]2=[O:16]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 122007766,7-Dihydroxychromon-3-carboxylic acid

생성물 1

HCID 127657576,7-Dihydroxy-4-oxo-4H-1-benzopyran-3-carbonyl chloride수율 93.4%

실험 절차

A mixture of 6,7-dihydroxychromone-3-carboxylic acid (9.0 g, 4 mmol) and thionyl chloride (150 ml) was refluxed for 45 minutes and the thionyl chloride was evaporated. After the addition of benzene, the mixture was evaporated again to dryness and the residue was triturated with n-hexane to afford the desired compound (9.1 g, 93.4%).

후처리

  1. temperaturewas refluxed for 45 minutes
  2. customthe thionyl chloride was evaporated
  3. additionAfter the addition of benzene
  4. customthe mixture was evaporated again to dryness
  5. customthe residue was triturated with n-hexane

출처 및 근거

ORD 기록
ord-116ccc2ab25c488290a07b55c7ee64d8
출처 데이터셋
uspto-grants-1981_08
특허 번호
US04285939

반응 노트

불러오는 중…