Thionyl Chloride → 7,8-Dihydroxychromone-3-carbonyl chloride

HRID 895007노트

반응식

HRID 895007 반응식
[OH:1][C:2]1[C:11]([OH:12])=[C:10]2[C:5]([C:6](=[O:16])[C:7]([C:13](O)=[O:14])=[CH:8][O:9]2)=[CH:4][CH:3]=1.S(Cl)([Cl:19])=O>>[OH:1][C:2]1[C:11]([OH:12])=[C:10]2[C:5]([C:6](=[O:16])[C:7]([C:13]([Cl:19])=[O:14])=[CH:8][O:9]2)=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 127658447,8-Dihydroxychromone-3-carboxylic acid

생성물 1

HCID 130830427,8-Dihydroxychromone-3-carbonyl chloride

실험 절차

A mixture of 7,8-dihydroxychromone-3-carboxylic acid (6.6 g, 30 mmol) and thionyl chloride (25 ml) was refluxed for one hour, and the thionyl chloride was removed. After the addition of benzene to the residue, the mixture was evaporated to dryness and the residue was triturated with n-hexane to give the desired compound (7.2 g).

후처리

  1. temperaturewas refluxed for one hour
  2. customthe thionyl chloride was removed
  3. additionAfter the addition of benzene to the residue
  4. customthe mixture was evaporated to dryness
  5. customthe residue was triturated with n-hexane

출처 및 근거

ORD 기록
ord-602cf728945244e888a8c3d8c9278467
출처 데이터셋
uspto-grants-1981_08
특허 번호
US04285941

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