Morpholine → 4-(2,6-Difluoro-4-nitrophenyl)morpholine

HRID 895122노트

반응식

HRID 895122 반응식
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[F:7][C:8]1[CH:9]=[C:10]([N+:16]([O-:18])=[O:17])[CH:11]=[C:12]([F:15])[C:13]=1F>C(#N)C>[F:7][C:8]1[CH:9]=[C:10]([N+:16]([O-:18])=[O:17])[CH:11]=[C:12]([F:15])[C:13]=1[N:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 27827931,2,3-Trifluoro-5-nitrobenzene

생성물 1

HCID 223856304-(2,6-Difluoro-4-nitrophenyl)morpholine수율 88%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Morpholine (1.2 g, 14.12 mmol) was added to a stirring solution of 3,4,5-trifluoronitro benzene (1 g, 5.65 mmol) in acetonitrile (15 mL) and the reaction mixture was refluxed for 5 h. A viscous liquid was obtained upon concentration, which was then poured into crushed ice. The solid thus obtained was filtered off and dried under reduced pressure to obtain the title compound (1.2 g, 88%).

후처리

  1. temperaturethe reaction mixture was refluxed for 5 h
  2. customA viscous liquid was obtained upon concentration, which
  3. additionwas then poured
  4. custominto crushed ice
  5. customThe solid thus obtained
  6. filtrationwas filtered off
  7. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-548753ebd41d4ba1b662c37df832ddeb
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06914058B2

반응 노트

불러오는 중…