2-Bromo-6-methoxynaphthalene → 2-Methoxy-6-phenylnaphthalene

HRID 895171

반응식

HRID 895171 반응식
Br[C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:12][CH3:13])[CH:8]=2)[CH:3]=1.[C:14]1([Mg]Br)[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH3:13][O:12][C:7]1[CH:6]=[CH:5][C:4]2[C:9](=[CH:10][CH:11]=[C:2]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH:3]=2)[CH:8]=1

참가 물질

3

반응물 2

HCID 787862-Bromo-6-methoxynaphthaleneHCID 178418255HCID 178418255, 화합물

생성물 1

HCID 112533082-Methoxy-6-phenylnaphthalene

실험 절차

The title compound was prepared by reacting 2-bromo-6-methoxynaphthalene (1.97 g, 8.31 mmol) with phenylmagnesium bromide according to the method used to prepare intermedite 10 to yield 1.59 g (82%) of a white solid: mp 122-126° C.; 1H NMR (CDCl3): δ 3.94 (3H, s), 7.16-7.18 (2H, m), 7.34-7.37 (1H, m), 7.46-7.49 (2H, m), 7.69-7.72 (2H, m), 7.78-7.82 (2H, m), 7.97 (1H, s); MS (EI) m/z 234.2 (M)+.

후처리

  1. customto prepare intermedite 10

출처 및 근거

ORD 기록
ord-03cfe8efc2894d9b9aa83c03efc97b70
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06914074B2

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