2-Methoxy-6-(4-methoxyphenyl)naphthalene → 6-(4-Hydroxyphenyl)-2-naphthol

HRID 895173

반응식

HRID 895173 반응식
C[O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([C:13]3[CH:18]=[CH:17][C:16]([O:19]C)=[CH:15][CH:14]=3)[CH:9]=2)[CH:4]=1.Cl.[NH+]1C=CC=CC=1>>[OH:19][C:16]1[CH:17]=[CH:18][C:13]([C:8]2[CH:9]=[C:10]3[C:5](=[CH:6][CH:7]=2)[CH:4]=[C:3]([OH:2])[CH:12]=[CH:11]3)=[CH:14][CH:15]=1

참가 물질

3

반응물 2

HCID 111497342-Methoxy-6-(4-methoxyphenyl)naphthaleneHCID 21584435Pyridinium hydrochloride

생성물 1

HCID 114590066-(4-Hydroxyphenyl)-2-naphthol수율 98%

실험 절차

2-Methoxy-6-(4-methoxyphenyl)naphthalene (5.61 g, 21.2 mmol) was added to pyridinium HCl (30 g) at 190° C. according to Method B to afford 4.88 g (98%) of a white solid: mp>220 (discolors above 200° C.); 1H NMR (DMSO-d6): δ 6.87 (2H, d, J=8.54 Hz), 7.08 (1H, dd, J=2.34 Hz, J=8.76 Hz), 7.11 (1H, d, J=2.14 Hz), 7.58 (2H, d, J=8.54 Hz), 7.65 (1H, dd, J=1.92 Hz, J=8.76 Hz), 7.71 (1H, d, J=8.54 Hz), 7.79 (1H, d, J=8.97 Hz), 7.95 (1H, s), 9.56 (1H, bs), 9.70 (1H, bs); MS (ESI) m/z 235 (M−H)−.

출처 및 근거

ORD 기록
ord-0969c2caeefb4771b215333c558824d7
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06914074B2

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