Bromine → 10-Bromophenanthrene-2-carboxylic acid

HRID 895377노트

반응식

HRID 895377 반응식
[CH:1]1[C:14]2[CH:13]=[CH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][C:2]=1[C:15]([OH:17])=[O:16].[Br:18]Br>C(O)(=O)C>[Br:18][C:13]1[C:14]2[CH:1]=[C:2]([C:15]([OH:17])=[O:16])[CH:3]=[CH:4][C:5]=2[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[CH:12]=1

참가 물질

4

반응물 2

HCID 24408Bromine2회HCID 13234903Phenanthrene-2-carboxylic acid

생성물 1

HCID 2237984810-Bromophenanthrene-2-carboxylic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
70 °C

실험 절차

Phenanthrene-2-carboxylic acid (1, 0.116 g, 0.5 mmol) was dissolved in acetic acid at 70° C. and then bromine (0.027 ml, 0.5 mmol) was added. The mixture was stirred at 70° C. overnight. The following day, bromine (0.027 ml, 0.5 mmol) was added and the mixture was refluxed for 6 h and then allowed to cool. The resulting precipitate was collected by filtration. 1H NMR (270 MHz, DMSO):—7.8 (m, 2H), 8.1 (d, 1H), 8.25 (d, 1H), 8.45 (s, 1H), 8.9 (s, 1H), 8.95 (m, 1H) and 9.05 (d, 1H).

후처리

  1. temperaturethe mixture was refluxed for 6 h
  2. temperatureto cool
  3. filtrationThe resulting precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-4e18be51a9044745aef627492e4254ac
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06916816B2

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