Potassium Hydroxide → 4-Ethinyl-1,5-dimethyl-3-(trifluoromethyl)-1h-pyrazole
반응식
Br[CH:2]([C:5]1[C:6]([C:12]([F:15])([F:14])[F:13])=[N:7][N:8]([CH3:11])[C:9]=1[CH3:10])[CH2:3]Br.[OH-].[K+]>C1(C)C=CC=CC=1>[C:2]([C:5]1[C:6]([C:12]([F:14])([F:15])[F:13])=[N:7][N:8]([CH3:11])[C:9]=1[CH3:10])#[CH:3]참가 물질
4
실험 절차
7.3 g (20.9 mmol) of 4-(1,2-dibromoethyl)-1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazole are taken up in 5 ml of toluene and heated to 70° C. for 12 h together with a 60% aqueous KOH solution (10 ml) and 1.2 g of polyethylene glycol 600. After the end of the reaction, the two phases are separated, the aqueous phase is extracted with toluene and the combined organic phases are dried over MgSO4 and concentrated. The product is obtained as a solid in an 81% yield.
후처리
- customAfter the end of the reaction
- customthe two phases are separated
- extractionthe aqueous phase is extracted with toluene
- dry with materialthe combined organic phases are dried over MgSO4
- concentrationconcentrated
- customThe product is obtained as a solid in an 81% yield
출처 및 근거
- ORD 기록
- ord-2deab906e34649328e8697086aeb03d8
- 출처 데이터셋
- uspto-grants-2005_07
- 특허 번호
- US06916839B2
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