Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 4-(6-Cyano-2-naphthyloxy)-3-(2-formylphenyl)nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | 2-Formylphenylboronic acid | HCID 292189 | — |
| 반응물 | HCID 22380923 | HCID 22380923 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Sodium Carbonate | HCID 10340 | — |
| 생성물 | 4-(6-Cyano-2-naphthyloxy)-3-(2-formylphenyl)nitrobenzene | HCID 22380967 | — |
반응 단계
The compound (3-bromo-4-(6-cyano-2-naphthyloxy)nitrobenzene) (1 g) obtained in a previous production example, 2-formylphenyl boronic acid (610 mg) and tetrakis(triphenylphosphine)palladium (0) (150 mg) were heated to reflux and reacted for 6 hours in a mixture of 2 M sodium carbonate aqueous solution (10 ml), toluene (10 ml) and ethanol (10 ml). After cooling to room temperature, water was added and extraction was performed with ethyl acetate. The ethyl acetate layer was washed with saturated saline and dried over magnesium sulfate, and the solvent was distilled off. The residue was purified by silica gel chromatography (200 g, hexane:ethyl acetate=4:1) to obtain 880 mg of 4-(6-cyano-2-naphthyloxy)-3-(2-formylphenyl)nitrobenzene.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06916837B2 |
| 출처 데이터셋 | uspto-grants-2005_07 |
| ORD ID | ord-00b3f9566f0247e989e5a7f00222f09f |
| 출처 메모 | uspto-grants-2005_07 |