Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 1-Benzyl-4-phenylpiperidine-4-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | 1-Benzyl-4-cyano-4-phenylpiperidine | HCID 191408 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 1-Benzyl-4-phenylpiperidine-4-carboxamide | HCID 96423 | — |
반응 단계
(a′) 1-benzyl-4-cyano-4-phenylpiperidine, prepared in situ via neutralization of its hydrochloride, is treated with 94-96% sulfuric acid and acetic acid in toluene at 80-100° C. and the 1-benzyl-4-phenyl-4-piperidinecarboxamide thus obtained is treated with bromine in the presence of sodium methoxide; and then
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06916929B2 |
| 출처 데이터셋 | uspto-grants-2005_07 |
| ORD ID | ord-724d21cdd37c4afd8037ad128005f9e1 |
| 출처 메모 | uspto-grants-2005_07 |