Methyl Isobutyl Ketone → N-Methyl-4-phenyl-4-piperidinamine

HRID 895793노트

반응식

HRID 895793 반응식
[OH-].[K+].CC(C)CC(=O)C.C(O)(=O)C(O)=O.C(O)(=O)C(O)=O.[CH3:22][NH:23][C:24]1([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>O>[CH3:22][NH:23][C:24]1([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]1

참가 물질

5

반응물 3

HCID 7909Methyl Isobutyl KetoneHCID 14797Potassium HydroxideHCID 86594304HCID 86594304, 화합물

생성물 1

HCID 9813005N-Methyl-4-phenyl-4-piperidinamine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

6.3 g of potassium hydroxide and 15 ml of 4-methyl-2-pentanone are added at 20° C. to a solution of 7.5 g of 4-methylamino-4-phenylpiperidine dioxalate in 30 ml of water. The mixture is stirred, the phases are separated by settling and the aqueous phase is discarded. The organic phase is concentrated to dryness and the oily residue is taken up in 15 ml of toluene. The toluene solution is dried over magnesium sulfate. The minerals are filtered off and the precipitate is rinsed with 5 ml of toluene and concentrated to dryness. 3.8 g of a colorless oil, which is 4-methylamino-4-phenylpiperidine base, are thus obtained in a purity of greater than 97%.

후처리

  1. customthe phases are separated
  2. concentrationThe organic phase is concentrated to dryness
  3. dry with materialThe toluene solution is dried over magnesium sulfate
  4. filtrationThe minerals are filtered off
  5. washthe precipitate is rinsed with 5 ml of toluene
  6. concentrationconcentrated to dryness
  7. customare thus obtained in a purity of greater than 97%

출처 및 근거

ORD 기록
ord-753a1fecf4254913b9c39b17dabe29c9
출처 데이터셋
uspto-grants-2005_07
특허 번호
US06916929B2

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